Education

Degrees and Coursework

M logoStem cell related courses at University of Wisconsin
http://www.stemcells.wisc.edu/node/81  

W logoStem Cell Biology M.S. degree University of Minnesota
http://www.stemcell.umn.edu/graduate_programs/master_of_science/home.html

Training Courses

Training courses on Human ES and iPS cell culture

W logoUniversity of Wisconsin
http://www.wicell.org/index.php?option=com_events&Itemid=149&sectionid=16&catid=78 

M logoUniversity of Minnesota
http://www.stemcell.umn.edu/hESCtraining/home.html

Training Fellowships

Each university has funds to appoint one senior postdoctoral/junior faculty level researcher to a training fellowship.

Requirements are:
1. The person appointed should work within the area of the Hub’s activity.
2. He/she should be based within one of the Hub P.I.’s labs.
3. Preference will be given to applicants who propose collaborative projects involving more than one Hub lab.
4. The person appointed should aim to obtain personal funding (e.g. K08, R21, R01, AHA-SDG) by the end of the fellowship.

Fellowships will be awarded for 1 year, extendable for a second year if progress is satisfactory.

M logoFor information about the University of Minnesota scheme,
please contact Dan Garry (garry@umn.edu).

W logoFor information about the University of Wisconsin scheme,
please contact Tim Kamp (tjk@medicine.wisc.edu).

Skills Development

The Midwestern Progenitor Cell Consortium is dedicated to advancing the understanding of the normal development of heart, blood and blood vessels, as well as to the technology of isolating, handling and transplanting the progenitor cells for these tissues and organs.

Our Skills Development Program is intended to enable all members of the constituent labs to improve their knowledge of relevant subject areas and of key technologies of importance. This page contains information about:

Background Reading

Heart Development

Heart Development

  • Brand, T. (2003). Heart development: molecular insights into cardiac specification and early morphogenesis. Developmental Biology 258, 1-19.
  • Eisenberg, L. M. and Markwald, R. R. (2004). Cellular recruitment and development of the myocardium. Developmental Biology 274, 225-232.
  • Masino, A. M., Gallardo, T. D., Wilcox, C. A., Olson, E. N., Williams, R. S. and Garry, D. J. (2004). Transcriptional regulation of cardiac progenitor cell populations. Circulation Research 95, 389-397.
  • Buckingham, M., Meilhac, S., and Zaffran, S. (2005). Building the mammalian heart from two sources of myocardial cells. Nature Reviews Genetics 6, 826-837.
  • Ramsdell, A. F. (2005). Left-right asymmetry and congenital cardiac defects: Getting to the heart of the matter in vertebrate left-right axis determination. Developmental Biology 288, 1-20.
  • Stennard, F. A. and Harvey, R. P. (2005). T-box transcription factors and their roles in regulatory hierarchies in the developing heart. Development 132, 4897-4910.
  • Simões-Costa, M. S., Vasconcelos, M., Sampaio, A.C., Cravo, R.M., Linhares, V.L., Hochgreb, T., Yan, C.Y.I., Davidson, B., and Xavier-Neto, J. (2005). The evolutionary origin of cardiac chambers. Developmental Biology 277, 1-15.
  • Srivastava, D. (2006). Making or breaking the heart: from lineage determination to morphogenesis. Cell 126, 1037-1048.
  • Olson, E. N. (2006). Gene regulatory networks in the evolution and development of the heart. Science 313, 1922-1927.
  • Garry, D.J. and Olson, E.N. (2006). A common progenitor at the heart of development. Cell 127, 1101-1104.
  • Abu-Issa, R. and Kirby, M. L. (2007). Heart Field: From Mesoderm to Heart Tube. Annual Review of Cell and Developmental Biology 23, 45-68.
  • Martin-Puig, S., Wang, Z. and Chien, K.R. (2008). Lives of a Heart Cell: Tracing the Origins of Cardiac Progenitors. Cell Stem Cell 2, 320-331.
  • Laugwitz, K.-L., Moretti, A., Caron, L., Nakano, A. and Chien, K.R. (2008). Islet1 cardiovascular progenitors: a single source for heart lineages? Development 135, 193-205.
  • Dyer, L.A. and Kirby, M.L. (2009). The role of secondary heart field in cardiac development. Developmental Biology 336, 137-144.
  • Musunuru, K, Domian, I.J. and Chien, K.R. (2010). Stem Cell Models of Cardiac Development and Disease. Annual Review of Cell and Developmental Biology 26, 667-687.

Heart Regeneration

Heart Regeneration

  • Garry, D. J. and Martin, C. M. (2004). Cardiac regeneration - Self-service at the pump. Circulation Research 95, 852-854.
  • Leri, A., Kajstura, J., and Anversa, P. (2005). Cardiac stem cells and mechanisms of myocardial regeneration. Physiological Reviews 85, 1373-1416.
  • Latif, S., Masino, A. and Garry, D. J. (2006). Transcriptional pathways direct cardiac development and regeneration. Trends in Cardiovascular Medicine 16, 234-240.
  • Poss, K. D. (2007). Getting to the heart of regeneration in zebrafish. Seminars in Cell & Developmental Biology 18, 36-45.
  • Borchardt, T. and Braun, T. (2007). Cardiovascular regeneration in non-mammalian model systems: What are the differences between newts and man? Thrombosis and Haemostasis 98, 311-318.
  • Anversa, P., Leri, A., Rota, M., Hosoda, T., Bearzi, C., Urbanek, K., Kajstura, J. and Bolli, R. (2007). Concise Review: Stem Cells, Myocardial Regeneration, and Methodological Artifacts. Stem Cells 25, 589-601.
  • Wu, S. M., Chien, K. R. and Mummery, C. (2008). Origins and Fates of Cardiovascular Progenitor Cells. Cell 132, 537-543.
  • Ausoni, S. and Sartore, S. (2009). From fish to amphibians to mammals: in search of novel strategies to optimize cardiac regeneration. Journal of Cell Biology 184, 357-364.
  • Laflamme, M.A. and Murry, C.E. (2011). Heart Regeneration. Nature 473, 326-335.

Blood development and hematopoietic system

Blood development and hematopoietic system

  • Kyba, M. and Daley, G. Q. (2003). Hematopoiesis from embryonic stem cells: Lessons from and for ontogeny. Experimental Hematology 31, 994-1006.
  • Kondo, M., Wagers, A. J., Manz, M. G., Prohaska, S. S., Scherer, D. C., Beilhack, G. F., Shizuru, J. A. and Weissman, I. L. (2003). Biology of Hematopoietic Stem Cells and Progenitors: Implications for Clinical Application. Annual Review of Immunology 21, 759-806.
  • Godin, I. and Cumano, A. (2005). Of birds and mice: hematopoietic stem cell development. International Journal of Developmental Biology 49, 251-257.
  • Orkin, S. H. and Zon, L. I. (2008). Hematopoiesis: An Evolving Paradigm for Stem Cell Biology. Cell 132, 631-644.
  • Oh, I.-H. and Kwon, K.-R. (2010). Concise Review:  Multiple Niches for Hematopoietic Stem Cell Regulations. Stem Cells 28, 1243-1249.
  • Medvinsky, A., Rybtsov, S. and Taoudi, S. (2011). Embryonic origin of the adult hematopoietic system:  advances and questions. Development 138, 1017-1031.
  • Wang, L.D. and Wagers, A.J. (2011). Dynamic niches in the origination and differentiation of haematopoietic stem cells. Nat Rev Mol Cell Biol 12, 643-655.
  • Adamo, L. and Garcia-Cardeña, G. (2012). The vascular origin of hematopoietic cells. Developmental Biology 362, 1-10.
  • Doulatov, S., Notta, F., Laurenti, E. and Dick, John E. (2012). Hematopoiesis:  A Human Perspective. Cell Stem Cell 10, 120-136.

Blood Vessel Development and Postnatal Angiogenesis

Blood Vessel Development and Postnatal Angiogenesis

  • Ribatti, D., Vacca, A., Nico, B., Roncali, L., and Dammacco, F. (2001). Postnatal vasculogenesis. Mechanisms of Development 100, 157-163.
  • Adams, R. H. (2003). Molecular control of arterial-venous blood vessel identity. Journal of Anatomy 202, 105-112.
  • Rossant, J. and Hirashima, M. (2003). Vascular development and patterning: making the right choices. Current Opinion in Genetics & Development 13, 408-412.
  • Carmeliet, P. (2003). Angiogenesis in health and disease. Nature Medicine 9, 653-660.
  • Kubo, H. a. A., K. (2003). The bloody fate of endothelial stem cells. Genes & Development 17, 322-329.
  • Carmeliet, P. (2005). Angiogenesis in life, disease, and medicine. Nature 438, 932-936.
  • Eichmann, A., Makinen, T., and Alitalo, K. (2005). Neural guidance molecules regulate vascular remodeling and vessel navigation. Genes & Development 19, 1013-1021.
  • Gridley, T. (2007). Notch signaling in vascular development and physiology. Development 134, 2709-2718.
  • Roca, C. and Adams, R. H. (2007). Regulation of vascular morphogenesis by Notch signaling. Genes Dev. 21, 2511-2524.
  • Phng, L. K. and Gerhardt, H. (2009). Angiogenesis: A Team Effort Coordinated by Notch. Developmental Cell 16, 196-208.
  • Herbert, S.P. and Stainier, D.Y.R. (2011). Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol 12, 551-564.

Some Relevant Aspects of Regenerative Medicine

Some Relevant Aspects of Regenerative Medicine

  • Kaufman, D. S. and Thomson, J. A. (2002). Human ES cells - haematopoiesis and transplantation strategies. Journal of Anatomy 200, 243-248.
  • Sorrentino, B. P. (2004). Clinical strategies for expansion of haematopoietic stem cells. Nature Reviews Immunology 4, 878-888.
  • Bordignon, C. (2006). Stem-cell therapies for blood diseases. Nature 441, 1100-1102.
  • Srivastava, D. and Ivey, K. N. (2006). Potential of stem-cell-based therapies for heart disease. Nature 441, 1097-1099.
  • Chien, K. R., Domian, I. J. and Parker, K. K. (2008). Cardiogenesis and the Complex Biology of Regenerative Cardiovascular Medicine. Science 322, 1494-1497.
  • Passier, R., van Laake, L. W. and Mummery, C. L. (2008). Stem-cell-based therapy and lessons from the heart. Nature 453, 322-329.
  • Weaver, C. V. and Garry, D. J. (2008). Regenerative biology: a historical perspective and modern applications. Regenerative Medicine 3, 63-82.
  • Segers, V. F. M. and Lee, R. T. (2008). Stem-cell therapy for cardiac disease. Nature 451, 937-942.
  • Hansson, E. M., Lindsay, M. E. and Chien, K. R. (2009). Regeneration Next: Toward Heart Stem Cell Therapeutics. Cell Stem Cell 5, 364-377.
  • Kamp, T. J. and Lyons, G. E. (2009). On the Road to iPS Cell Cardiovascular Applications. Circulation Research 105, 617-619.
  • Burridge, Paul W., Keller, G., Gold, Joseph D. and Wu, Joseph C. (2012). Production of De Novo Cardiomyocytes:  Human Pluripotent Stem Cell Differentiation and Direct Reprogramming. Cell Stem Cell 10, 16-28.
  • Maury, Y., Gauthier, M., Peschanski, M. and Martinat, C. (2012). Human pluripotent stem cells for disease modelling and drug screening. BioEssays 34, 61-71.