Perlingeiro Lab

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Our laboratory has a long-term interest in understanding the molecular mechanisms controlling lineage-specific differentiation of pluripotent stem cells (i.e. embryonic and adult reprogrammed stem cells), and applying this information to efficiently generate tissue-specific stem/progenitor cells endowed with in vivo regenerative potential. Our ultimate goal is to develop safe strategies to enable their future therapeutic application.

Rita Perlingeiro, PhD
Professor of Medicine

Cardiovascular Division

perli032@umn.edu

Full bio

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Current Research Projects

  • Transcriptional mechanisms and signaling pathways controlling mesodermal cell fate
  • Strategies to enable translational application of iPS cells to treat muscular dystrophies
  • Genetic correction of disease- and patient-specific iPS cells
  • Dissecting the mechanisms associated with stem cell self-renewal and long-term engraftment

Selected Publications

Full list of publications at Experts@Minnesota.

  1. Baik J, Magli A, Tahara N, Swanson SA, Borges L, Koyano-Nakagawa N, Stewart R, Garry DG,  Kawakami Y, Thomson JA & Perlingeiro RCR. "Endoglin Integrates BMP and Wnt Signaling to Induce Hematopoiesis through JDP2." Nature Communications. (in press).
  2. Carrió E, Magli A, Muñoz M, Peinado MA, Perlingeiro RCR, & Suelves M. "Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation." BMC Biology. 2016:14:30. PMCID: PMC in progress.
  3. Filareto A, Rinaldi F, Arpke RW, Darabi R, Belanto JJ, Toso EA,  Miller AZ, Ervasti JM, McIvor RS, Kyba M, & Perlingeiro RCR. "Pax3-induced expansion enables the genetic correction of dystrophic satellite cells." Skeletal Muscle. 2015:5:36. PMCID: PMC4620645
  4. McCullagh KJA & Perlingeiro RCR. "Coaxing stem cells for skeletal muscle repair." Advanced Drug Delivery Reviews. 2015:84:198-207. PMID: 25049085.
  5. Skoglund G, Laine J, Darabi R, Fournier E, Perlingeiro RCR, Tabti N, (2014) “Physiological and ultrastructural features of human induced pluripotent and embryonic stem cell-derived skeletal myocytes in vitro.” Proc Natl Acad Sci USA. 111:8275-8280.
  6. Magli A, Schnettler E, Swanson SA, Borges L, Hoffman K, Stewart R, Thomson JA, Perlingeiro RCR, (2014) “Pax3 and Tbx5 specify whether PDGFRα+ cells assume skeletal or cardiac muscle fate in differentiating ES cells”. Stem Cells, 32:2072-2083. PMID: 24677751.
  7. Filareto A, Parker S, Darabi R, Borges L, Iacovino M, Schaaf T, Mayerhofer T, Chamberlain JS, Ervasti JM, McIvor RS, Kyba M, Perlingeiro RCR, (2013) “An Ex Vivo Gene Therapy Approach to Treat Muscular Dystrophy Using Inducible Pluripotent Stem Cells” Nat Communication, Mar 5;4:1549. PMID: 23462992.
  8. Magli A, Schnettler E, Rinaldi F, Brember P, Perlingeiro RCR, (2013) “Functional Dissection of Pax3 in Paraxial Mesoderm Development and Myogenesis” Stem Cells, Jan; 31(1):59-60. PMID: 23081715.
  9. Borges L, Iacovino M, Mayerhofer T, Koyano-Nakagawa N, Baik J, Garry DJ, Kyba M, Letarte M, Perlingeiro RCR, (2012) “A Critical Role for Endoglin in the Emergence of Blood During Embryonic Development” Blood, Jun 7;119(23):5417-5428. PMID: 22535663.
  10. Darabi R, Arpke RW, Irion S, Dimos JT, Grskovic M, Kyba M, Perlingeiro RCR, (2012) "Human ES- and iPS-Derived Myogenic Progenitors Restore DYSTROPHIN and Improve Contractility upon Transplantation in Dystrophic Mice"Cell Stem Cell, May 4;10(5):610-9. PMID:22560081.
  11. Darabi R, Santos FNC, Filareto A, Pan W, Koene R, Rudnicki M, Kyba M, Perlingeiro RCR, (2011) "Assessment of the Myogenic Stem Cell Compartment Following Transplantation of Pax3/Pax7-Induced Embryonic Stem Cell-Derived Progenitors" Stem Cells, 29:777-790.
  12. Perlingeiro RCR, (2007) "Endoglin is required for hemangioblast and early hematopoietic development"Development, 134:3041-3048.

Full list of publications at Experts@Minnesota

Lab Members