Kamdar Lab

Forum KamdarForum Kamdar, MDThe Kamdar lab is investigating molecular mechanisms of advanced heart failure in neuromuscular cardiomyopathy. We utilize a bench-to-bedside approach using patient derived-human induced pluripotent stem cell cardiomyocyte model and human heart tissues with the ultimate goal of developing new therapies to benefit patients.

Forum Kamdar faculty profile >

 

 

Current Research Projects

  • Unlocking the Role of the Cardiac Calcium Pump SERCA2A Dysregulation in DMD Cardiomyopathy
  • Advanced Heart Failure Therapies in Neuromuscular Cardiomyopathies

Lab Members

  • Phillip Bidwell, Ph.D. Research Associate
  • Walker Kreppes, M.S. Scientist

Selected Publications

  1. Kamdar F, Garry DJ. Dystrophin-Deficient Cardiomyopathy. J Am Coll Cardiol. 2016 May 31;67(21):2533-46. doi: 10.1016/j.jacc.2016.02.081. PMID: 27230049.
  2. Stroik DR, Ceholski DK, Bidwell PA, Mleczko J, Thanel PF, Kamdar F, Autry JM, Cornea RL, Thomas DD. Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs. J Mol Cell Cardiol. 2020 Jan;138:59-65. doi: 10.1016/j.yjmcc.2019.11.147. Epub 2019 Nov 18. PMID: 31751570; PMCID: PMC7035975.
  3. Kamdar F, Das S, Gong W, Klaassen Kamdar A, Meyers TA, Shah P, Ervasti JM, Townsend D, Kamp TJ, Wu JC, Garry MG, Zhang J, Garry DJ. Stem Cell-Derived Cardiomyocytes and Beta-Adrenergic Receptor Blockade in Duchenne Muscular Dystrophy Cardiomyopathy. J Am Coll Cardiol. 2020 Mar 17;75(10):1159-1174. doi: 10.1016/j.jacc.2019.12.066. PMID: 32164890.
  4. Albert CL, Kamdar F, Hanna M. Contemporary Controversies in Digoxin Use in Systolic Heart Failure. Curr Heart Fail Rep. 2016 Oct;13(5):197-206. doi: 10.1007/s11897-016-0302-z. PMID: 27696142.
  5. Strakova J, Kamdar F, Kulhanek D, Razzoli M, Garry DJ, Ervasti JM, Bartolomucci A, Townsend D. Integrative effects of dystrophin loss on metabolic function of the mdx mouse. Sci Rep. 2018 Sep 11;8(1):13624. doi: 10.1038/s41598-018-31753-3. PMID: 30206270; PMCID: PMC6134145.
  6. Kamdar F, Jameel MN, Score P, Zhang J. Cellular therapy promotes endogenous stem cell repair. Can J Physiol Pharmacol. 2012 Oct;90(10):1335-44. doi: 10.1139/y2012-115. Epub 2012 Sep 28. PMID: 23020202; PMCID: PMC3639124.
  7. Kamdar F, Klaassen Kamdar A, Koyano-Nakagawa N, Garry MG, Garry DJ. Cardiomyopathy in a dish: using human inducible pluripotent stem cells to model inherited cardiomyopathies. J Card Fail. 2015 Sep;21(9):761-70. doi: 10.1016/j.cardfail.2015.04.010. Epub 2015 Apr 28. PMID: 25934595; PMCID: PMC4554831.
  8. Schultz J, John R, Martin C, Kamdar F, Thenappan T, Cogswell R. Prevalence of Myocardial Fibrosis by Left Ventricular Assist Device Apical Core Biopsy and Correlation with Other Markers of Myocardial Recovery. ASAIO J. 2019 Feb;65(2):123-126. doi: 10.1097/MAT.0000000000000774. PMID: 29533251.
  9. Kamdar F, Thenappan T, Missov E. Pulmonary arterial hypertension in von Recklinghausen's disease. Am J Med. 2015 Oct;128(10):e39-40. doi: 10.1016/j.amjmed.2015.06.005. Epub 2015 Jul 2. PMID: 26144102.
  10. Kamdar F, Hertz M, Shumway S, Missov E. Late effusive-constrictive pericarditis after lung transplantation. Am J Med. 2015 Jun;128(6):e1-2. doi: 10.1016/j.amjmed.2014.12.017. Epub 2014 Dec 30. PMID: 25555547.

Full list of publications at Experts@Minnesota.